國家衛生研究院 NHRI:Item 3990099045/13413
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    题名: Advances in understanding mitochondrial microRNAs (mitomiRs) on the pathogenesis of triple-negative breast cancer (TNBC)
    作者: Lin, HY;Chu, PY
    贡献者: National Institute of Cancer Research
    摘要: Triple-negative breast cancer (TNBC) is characterized by poor outcome and the most challenging breast cancer type to treat worldwide. TNBC manifests distinct profile of mitochondrial functions, which dictates reprogrammed metabolism, fosters tumor progression, and notably serves as therapeutic targets. Mitochondrial microRNAs (mitomiRs) are a group of microRNAs that critically modulate mitochondrial homeostasis. By a pathway-centric manner, mitomiRs tightly orchestrate metabolic reprogramming, redox status, cell apoptosis, mitochondrial dynamics, mitophagy, mitochondrial DNA (mtDNA) maintenance, and calcium balance, leading to an emerging field of study in various cancer types, including TNBC. We herein review the recent insights into the roles and mechanism of mitomiRs in TNBC and highlight its clinical value in diagnosis and prognosis as well as vital advances on therapeutics of preclinical and clinical studies.
    日期: 2021-03-21
    關聯: Oxidative Medicine and Cellular Longevity. 2021 Mar 21;2021:Article number 5517777.
    Link to: http://dx.doi.org/10.1155/2021/5517777
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000637391400004
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104098899
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