國家衛生研究院 NHRI:Item 3990099045/13355
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    題名: Aggressive organ penetration and high vector transmissibility of epidemic dengue virus-2 Cosmopolitan genotype in a transmission mouse model
    作者: Lin, JJ;Chung, PJ;Dai, SS;Tsai, WT;Lin, YF;Kuo, YP;Tsai, KN;Chien, CH;Tsai, DJ;Wu, MS;Shu, PY;Yueh, A;Chen, HW;Chen, CH;Yu, GY
    貢獻者: National Institute of Infectious Diseases and Vaccinology;National Mosquito-Borne Diseases Control Research Center;Institute of Biotechnology and Pharmaceutical Research
    摘要: Dengue virus (DENV) causes dengue fever and severe hemorrhagic fever in humans and is primarily transmitted by Aedes aegypti and A. albopictus mosquitoes. The incidence of DENV infection has been gradually increasing in recent years due to global urbanization and international travel. Understanding the virulence determinants in host and vector transmissibility of emerging epidemic DENV will be critical to combat potential outbreaks. The DENV serotype 2 (DENV-2), which caused a widespread utbreak in Taiwan in 2015 (TW2015), is of the Cosmopolitan genotype and is hylogenetically related to the virus strain linked to another large outbreak in Indonesia in 2015. We found that the TW2015 virus was highly virulent in type I and type II interferon-deficient mice, with robust replication in spleen, lung, and intestine. The TW2015 virus also had high transmissibility to Aedes mosquitoes and could be effectively spread in a continuous mosquitoes-mice-mosquitoes-mice transmission cycle. By making 16681-based mutants carrying different segments of the TW2015 virus, we identified structural pre-membrane (prM) and envelope (E) genes as key virulence determinants in the host, with involvement in the high transmissibility of the TW2015 virus in mosquitoes. The transmission mouse model will make a useful platform for evaluation of DENV with high epidemic potential and development of new strategies against dengue outbreaks.
    日期: 2021-03-30
    關聯: PLoS Pathogens. 2021 Mar 30;17(3):Article number e1009480.
    Link to: http://dx.doi.org/10.1371/journal.ppat.1009480
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1553-7366&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000634951800001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85104209959
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