國家衛生研究院 NHRI:Item 3990099045/1334
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    题名: Induction of a distinct CD8 Tnc17 subset by transforming growth factor-beta and interleukin-6
    作者: Liu, SJ;Tsai, JP;Shen, CR;Sher, YP;Hsieh, CL;Yeh, YC;Chou, AH;Chang, SR;Hsiao, KN;Yu, FW;Chen, HW
    贡献者: Vaccine Research and Development Center
    摘要: Cross-talk between TGF-beta and IL-6 has been shown to direct the differentiation of CD4(+) cells into special IL-17-secreting cells, which are termed Th17 cells. In this study, we demonstrated that TGF-beta and IL-6 could stimulate CD8(+) cells to differentiate into noncytotoxic, IL-17-producing cells in MLC. These IL-17-producing CD8(+) cells exhibit a unique granzyme B- IFN-gamma-IL-10-phenotype. The mRNA level of Th2/T cytotoxic 2 (Tc2) transcription factors GATA3 and Th1/Tc1 transcription factors T-box expressed in T cell (T-bet) as well as its target H2 center dot O-like homeobox (Hlx) is decreased in CD8(+) cells from TGF-beta and IL-6-treated MLC. In addition, these CD8(+) cells display a marked up-regulation of retinoic acid-related orphan receptor-gamma t, a key IL-17 transcription factor. These results demonstrate that the existence of an IL-17producing CD8(+) subset belongs to neither the Tc1 nor the Tc2 subset and can be categorized as a T noncytotoxic 17 (Tnc17) subset.
    关键词: Cell Biology;Hematology;Immunology
    日期: 2007-08-01
    關聯: Journal of Leukocyte Biology. 2007 Aug;82(2):354-360.
    Link to: http://dx.doi.org/10.1189/jlb.0207111
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0741-5400&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000248358500022
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=34547769911
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