國家衛生研究院 NHRI:Item 3990099045/13340
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    題名: Effectiveness of the Nanosilver/TiO2-chitosan antiviral filter on the removal of viral aerosols
    作者: Wang, IJ;Chen, YC;Su, C;Tsai, MH;Shen, WT;Bai, CH;Yu, KP
    貢獻者: National Institute of Environmental Health Sciences
    摘要: Background: The precaution of airborne transmission of viruses, such as influenza, SARS, MERS, and COVID-19, is essential for reducing infection. In this study, we applied a zero-valent nanosilver/titania-chitosan (nano-Ag-0/TiO2-CS) filter bed, whose broad-spectrum antimicrobial efficacy has been proven previously, for the removal of viral aerosols to minimize the risk of airborne transmission. Methods: The photochemical deposition method was used to synthesize the nano-Ag-0/TiO2-CS antiviral material. The surface morphology, elemental composition, and microstructure of the nano-Ag-0/TiO2-CS were analyzed by a scanning electron microscopy/energy dispersive X-ray spectroscopy and a transmission electron microscopy, respectively. The MS2 bacteriophages were used as surrogate viral aerosols. The antiviral efficacy of nano-Ag-0/TiO2-CS was evaluated by the MS2 plaque reduction assay (PRA) and filtration experiments. In the filtration experiments, the MS2 aerosols passed through the nano-Ag-0/TiO2-CS filter, and the MS2 aerosol removal efficiency was evaluated by an optical particle counter and culture method. Results and Conclusions: In the MS2 PRA, 3 g of nano-Ag-0/TiO2-CS inactivated 97% of MS2 bacteriophages in 20 mL liquid culture (2 +/- 0.5 x 10(16) PFU/mL) within 2 hours. The removal efficiency of nano-Ag-0/TiO2-CS filter (thickness: 6 cm) for MS2 aerosols reached up to 93%. Over 95% of MS2 bacteriophages on the surface of the nano-Ag-0/TiO2-CS filter were inactivated within 20 minutes. The Wells-Riley model predicted that when the nano-Ag-0/TiO2-CS filter was used in the ventilation system, airborne infection probability would reduce from 99% to 34.6%. The nano-Ag-0/TiO2-CS filter could remain at 50% of its original antiviral efficiency after continuous operation for 1 week, indicating its feasibility for the control of the airborne transmission.
    日期: 2021-09
    關聯: Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2021 Sep;34(5):293-302.
    Link to: http://dx.doi.org/10.1089/jamp.2020.1607
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1941-2711&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000634628300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116299412
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