國家衛生研究院 NHRI:Item 3990099045/13278

NHRI > National Institute of Environmental Health Sciences > Pau-Chung Chen > Periodical Articles > Item 3990099045/13278

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13278

Title:	Associations between infant developmental delays and secondhand smoke exposure modified by maternal pre-pregnancy overweight and obesity status
Authors:	Wei, CF;Lin, CC;Tsai, MS;Guo, YL;Lin, SJ;Liao, HF;Hsieh, WS;Chen, MH;Chen, PC
Contributors:	National Institute of Environmental Health Sciences;Institute of Population Health Sciences
Abstract:	BACKGROUND: Secondhand smoke exposure during pregnancy has long been associated with adverse health outcomes in children, but only a few studies have examined its effect modifiers. In this study, we applied effect modification analysis for maternal pre-pregnancy weight status on detrimental neurodevelopmental effect of secondhand smoke exposure during pregnancy and infancy in a nation-wide representative population. METHODS: Term singleton mother-infant pairs with non-smoking mothers were included for main analysis (N=15,987) from the Taiwan Birth Cohort Study (TBCS), and were further matched with propensity score (n=5,434). We extracted secondhand smoke exposure during pregnancy and infancy, and eight neurodevelopmental milestones from the responses in the baseline visit at six months, and eighteen months follow-up of TBCS. The associations between secondhand smoke exposure and neurodevelopmental achievement were analysed with multivariable logistic regression and Cox model. Propensity score weighting and matching were applied for high-versus-low analysis, and relative excess risk due to interaction were used to estimate effect modification. RESULTS: Higher secondhand smoke exposure was associated with increased likelihood of delayed milestone achievement across gross motor, fine motor, language-related and social-related domains. The associations in fine motor domains remained observable in propensity score weighted and matched models. We identified additive interaction with self-reported maternal overweight and obesity status before pregnancy in milestone development for walking with support, scribbling and waving goodbye. CONCLUSION: Secondhand smoke exposure during pregnancy and infancy were associated with delayed neurodevelopmental milestone achievement at eighteen months, and the associations were modified by maternal pre-pregnancy overweight and obesity status.
Date:	2021-09
Relation:	Nicotine and Tobacco Research. 2021 Sep;23(9):1475-1483.
Link to:	http://dx.doi.org/10.1093/ntr/ntab024
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1462-2203&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000730596600002
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85116957676
Appears in Collections:	[Pau-Chung Chen] Periodical Articles [Mei-Huei Chen] Periodical Articles [Yue-Liang Guo] Periodical Articles

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