國家衛生研究院 NHRI:Item 3990099045/13264
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    题名: Effect of triclosan on the pathogenesis of allergic diseases among children
    作者: Lin, MH;Chiu, SY;Ho, WC;Chi, KH;Liu, TY;Wang, IJ
    贡献者: Institute of Population Health Sciences;National Institute of Environmental Health Sciences
    摘要: BACKGROUND: Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children. OBJECTIVE: This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex. METHODS: Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated. RESULTS: The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys. SIGNIFICANCE: TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.
    日期: 2022-01
    關聯: Journal of Exposure Science and Environmental Epidemiology. 2022 Jan;32(1):60-68.
    Link to: http://dx.doi.org/10.1038/s41370-021-00304-w
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1559-0631&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000624370700003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85102079187
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