國家衛生研究院 NHRI:Item 3990099045/13243
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    題名: Altered sensory nerve excitability in fibromyalgia
    作者: Teng, HW;Tani, J;Chang, TS;Chen, HJ;Lin, YC;Lin, CS;Sung, JY
    貢獻者: NHRI Graduate Student Program
    摘要: BACKGROUND/PURPOSE: To investigate nerve excitability changes in patients with fibromyalgia and the correlation with clinical severity. METHODS: We enrolled 20 subjects with fibromyalgia and 22 sex and age-matched healthy subjects to receive nerve excitability test and nerve conduction study to evaluate the peripheral axonal function. RESULTS: In the fibromyalgia cohort, the sensory axonal excitability test revealed increased superexcitability (%) (P = 0.029) compared to healthy control. Correlational study showed a negative correlation between increased subexcitability (%) (r = -0.534, P = 0.022) with fibromyalgia impact questionnaire (FIQ) score. Computer modeling confirmed that the sensory axon excitability pattern we observed in fibromyalgia cohort was best explained by increased Barrett-Barrett conductance, which was thought to be attributed to paranodal fast K(+) channel dysfunction. CONCLUSION: The present study revealed that paranodal sensory K(+) conductance was altered in patients with fibromyalgia. The altered conductance indicated dysfunction of paranodal fast K(+) channels, which is known to be associated with the generation of pain.
    日期: 2021-08
    關聯: Journal of the Formosan Medical Association. 2021 Aug;120(8):1611-1619.
    Link to: http://dx.doi.org/10.1016/j.jfma.2021.02.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0929-6646&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000745765400010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101515354
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