國家衛生研究院 NHRI:Item 3990099045/13242

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Title:	Briarenols W-Z: Chlorine-containing polyoxygenated briaranes from octocoral briareum stechei (Kükenthal, 1908)
Authors:	Chen, YY;Zhang, YL;Lee, GH;Tsou, LK;Zhang, MM;Hsieh, HP;Chen, JJ;Ko, CY;Wen, ZH;Sung, PJ
Contributors:	Institute of Biotechnology and Pharmaceutical Research;Institute of Molecular and Genomic Medicine
Abstract:	Briareum stechei is proven to be a rich source of 3,8-cyclized cembranoids (briarane) with a bicyclo[8.4.0] carbon core. In the present study, four previously unreported briaranes, briarenols W-Z (1-4), along with solenolide A (5), briarenolide M (6), briaexcavatolide F (7), and brianolide (8), were isolated and characterized through spectroscopic analysis, and the absolute configuration of 8 was corroborated by a single-crystal x-ray diffraction analysis. Briaranes 2 and 5 were found to induce significant inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophage cells by enhancing the expression of the inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins.
Date:	2021-01-31
Relation:	Marine Drugs. 2021 Jan 31;19(2):Article number 77.
Link to:	http://dx.doi.org/10.3390/md19020077
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1660-3397&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000622689300001
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85101452892
Appears in Collections:	[Hsing-Pang Hsieh] Periodical Articles [Lun Kelvin Tsou] Periodical Articles [Mingzi M. Zhang] Periodical Articles

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