國家衛生研究院 NHRI:Item 3990099045/13240
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    题名: CRISPR-Cas strategies for natural product discovery and engineering in actinomycetes
    作者: Heng, E;Tan, LL;Zhang, MM;Wong, FT
    贡献者: Institute of Molecular and Genomic Medicine
    摘要: Fueled by CRISPR-Cas technology, a synergistic combination of advances in genomics, synthetic biology and bioinformatics have ushered in an era of genome-guided natural product discovery and engineering. As a versatile, programmable DNA targeting tool, CRISPR-Cas is increasingly employed to accelerate host and pathway engineering of actinomycetes, which are prolific producers of bioactive natural products. Here, we discuss the current state of the art, challenges and opportunities of CRISPR-Cas strategies to discover, diversify and improve the production of natural products from actinomycetes. Special emphasis is placed on the rapidly expanding CRISPR-Cas toolboxes for genome editing of non-Streptomyces actinomycetes.
    日期: 2021-03
    關聯: Process Biochemistry. 2021 Mar;102:261-268.
    Link to: http://dx.doi.org/10.1016/j.procbio.2021.01.007
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1359-5113&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000621436000009
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85100016552
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