國家衛生研究院 NHRI:Item 3990099045/13205
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    题名: Infantile infection and antibiotic exposure in association with pediatric psoriasis development: A nationwide nested case-control study
    作者: Chen, YJ;Ho, HJ;Wu, CY;Juan, CK;Wu, CY
    贡献者: National Institute of Cancer Research
    摘要: Background: Microbiol dysbiosis and antibiotic exposure have been implicated in the pathogenesis of pediatric inflammatory diseases. Objectives: To investigate the impacts of infantile infection and antibiotic exposure on pediatric psoriasis development. Methods: This is a nationwide nested case-control study. From the National Health Insurance Research Database of Taiwan, a total of 1527 patients with pediatric psoriasis were identified and matched with 15,270 reference individuals without psoriasis, for the period of 2000 to 2017. Demographic characteristics and comorbidities were compared. Conditional stepwise logistic regression analysis was conducted to examine the associations. Results: The mean ages were 9.9 ± 3.7 years in both groups. Atopic dermatitis (adjusted odds ratio [aOR], 2.07; 95% confidence interval [CI], 1.84-2.32) and family history of psoriasis, especially of the mother (aOR, 9.86; 95% CI, 6.89-14.10) or other first-degree relatives (aOR, 5.49; 95% CI, 3.91-7.70), were independently associated with pediatric psoriasis on multivariate analyses. Skin viral and bacterial infections (aOR, 1.35; 95% CI, 1.13-1.62) and fungal infections (aOR, 1.71; 95% CI, 1.44-2.04) in the first 2 years of life were significantly associated with pediatric psoriasis. Systemic antibiotic exposure was not. These results were consistent at different time periods across sensitivity analyses. Limitation: Information about diet and lifestyle was not available. Conclusion: Skin infections at an early age were associated with pediatric psoriasis development.
    日期: 2021-09-01
    關聯: Journal of the American Academy of Dermatology. 2021 Sep 01;85(3):626-635.
    Link to: http://dx.doi.org/10.1016/j.jaad.2020.12.014
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0190-9622&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000683573600015
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85099314008
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