國家衛生研究院 NHRI:Item 3990099045/13137
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/13137


    Title: Establishment of an immunocompetent metastasis rat model with hepatocyte cancer stem cells
    Authors: Wu, S;Tseng, IC;Huang, WC;Su, CW;Lai, YH;Lin, C;Lee, AYL;Kuo, CY;Su, LY;Lee, MC;Hsu, TC;Yu, CH
    Contributors: National Institute of Cancer Research
    Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer mortality. Cancer stem cells (CSCs) are responsible for the maintenance, metastasis, and relapse of various tumors. The effects of CSCs on the tumorigenesis of HCC are still not fully understood, however. We have recently established two new rat HCC cell lines HTC and TW-1, which we isolated from diethylnitrosamine-induced rat liver cancer. Results showed that TW-1 expressed the genetic markers of CSCs, including CD133, GSTP1, CD44, CD90, and EpCAM. Moreover, TW-1 showed higher tolerance to sorafenib than HTC did. In addition, tumorigenesis and metastasis were observed in nude mice and wild-type rats with TW-1 xenografts. Finally, we combined highly expressed genes in TW-1/HTC with well-known biomarkers from recent HCC studies to predict HCC-related biomarkers and able to identify HCC with AUCs > 0.9 after machine learning. These results indicated that TW-1 was a novel rat CSC line, and the mice or rat models we established with TW-1 has great potential on HCC studies in the future.
    Date: 2020-12-11
    Relation: Cancers. 2020 Dec 11;12(12):Article number 3721.
    Link to: http://dx.doi.org/10.3390/cancers12123721
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2072-6694&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000601643300001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097773199
    Appears in Collections:[Alan Yueh-Luen Lee] Periodical Articles

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