國家衛生研究院 NHRI:Item 3990099045/13066
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    题名: Type IIb heat labile enterotoxin B subunit as a mucosal adjuvant to enhance protective immunity against H5N1 avian influenza viruses
    作者: Tang, N;Lu, CY;Sue, SC;Chen, TH;Jan, JT;Huang, MH;Huang, CH;Chen, CC;Chiang, BL;Huang, LM;Wu, SC
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Human infections with highly pathogenic avian influenza H5N1 viruses persist as a major global health concern. Vaccination remains the primary protective strategy against H5N1 and other novel avian influenza virus infections. We investigated the use of E. coli type IIb heat labile enterotoxin B subunit (LTIIb-B5) as a mucosal adjuvant for intranasal immunizations with recombinant HA proteins against H5N1 avian influenza viruses. Use of LTIIb-B5 adjuvant elicited more potent IgG, IgA, and neutralizing antibody titers in both sera and bronchoalveolar lavage fluids, thus increasing protection against lethal virus challenges. LTIIb-B5 mucosal adjuvanticity was found to trigger stronger Th17 cellular response in spleen lymphocytes and cervical lymph nodes. Studies of anti-IL-17A monoclonal antibody depletion and IL-17A knockout mice also suggest the contribution from Th17 cellular response to anti-H5N1 protective immunity. Our results indicate a link between improved protection against H5N1 live virus challenges and increased Th17 response due to the use of LTIIb-B5 mucosal adjuvant with HA subunit proteins.
    日期: 2020-11-30
    關聯: Vaccines. 2020 Nov 30;8(4):Article number 710.
    Link to: http://dx.doi.org/10.3390/vaccines8040710
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2076-393X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000601669900001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097194236
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