國家衛生研究院 NHRI:Item 3990099045/13051

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Title:	Alteration in angiotensin-converting enzyme 2 by PM(1) during the development of emphysema in rats
Authors:	Chuang, HC;Chen, YY;Hsiao, TC;Chou, HC;Kuo, HP;Feng, PH;Ho, SC;Chen, JK;Chuang, KJ;Lee, KY
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	INTRODUCTION: Angiotensin-converting enzyme 2 (ACE2) provides an adhesion site for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Patients with COPD could have severe outcomes after SARS-CoV-2 infection. The objective of this study was to investigate ACE2 regulation by air pollution during the development of COPD. METHODS: Sprague Dawley rats were exposed to unconcentrated traffic-related air pollution for 3 and 6 months. We examined lung injury markers, oxidative stress, inflammation, emphysema, ACE2 and angiotensin II receptor type 1 (AT1) and 2 (AT2) in the lungs after exposure. RESULTS: Lung injury occurred due to an increase in permeability and lactate dehydrogenase cytotoxicity was observed after 6 months of exposure to fine particulate matter of <1 μm in aerodynamic diameter (PM(1)). An α(1)-antitrypsin deficiency and neutrophil elastase production with emphysema development were observed after 6 months of PM(1) exposure. 8-isoprostane and interleukin-6 were increased after 3 and 6 months of PM(1) exposure. Caspase-3 was increased after exposure to PM(1) for 6 months. Upregulation of ACE2 was found after 3 months of PM(1) exposure; however, ACE2 had decreased by 6 months of PM(1) exposure. AT1 and AT2 had significantly decreased after exposure to PM(1) for 6 months. Furthermore, smooth muscle hypertrophy had occurred after 6 months of PM(1) exposure. CONCLUSIONS: In conclusion, short-term exposure to PM(1) increased the ACE2 overexpression in lungs. Long-term exposure to PM(1) decreased the ACE2 overexpression in emphysema. Air pollution may be a risk for SARS-CoV-2 adhesion during the development of COPD.
Date:	2020-10
Relation:	ERJ Open Research. 2020 Oct;6(4):Article number 00174-2020.
Link to:	http://dx.doi.org/10.1183/23120541.00174-2020
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2312-0541&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000603682700032
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85089815951
Appears in Collections:	[Jen-Kun Chen] Periodical Articles

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