國家衛生研究院 NHRI:Item 3990099045/13046
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 855071      線上人數 : 959
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/13046


    題名: c-Myc promotes lymphatic metastasis of pancreatic neuroendocrine tumor through VEGFC upregulation
    作者: Chang, TM;Chu, PY;Hung, WC;Shan, YS;Lin, HY;Huang, KW;Chang, JS;Chen, LT;Tsai, HJ
    貢獻者: National Institute of Cancer Research
    摘要: Pancreatic neuroendocrine tumor (pNET) is a pancreatic neoplasm with neuroendocrine differentiation. pNET in early stage can be treated with surgical resection with long-term survival whereas the prognosis of pNET with locoregional or distant metastasis is relatively poor. Lymphangiogenesis is essential for tumor metastasis via lymphatic system and may overhead distant metastasis. c-Myc overexpression is involved in tumorigenesis. The role of c-Myc in lymphangiogenesis is unclear. In this study, we evaluated the mechanism and effect of c-Myc on lymphangiogenesis of pNET via interaction of lymphatic endothelial cells (LECs) and pNET cells. Lymph node metastasis was evaluated in pNET xenograft mice. Potential target agents to inhibit lymph node metastasis were evaluated in animal model. We found that vascular endothelial growth factor C (VEGFC) expression and secretion was increased in pNET cell lines with c-Myc overexpression. c-Myc transcriptionally upregulates VEGFC expression and secretion of pNET cells through direct binding to E-box of VEGFC promoter and enhanced VEGF receptor 3 phosphorylation and tube formation of LECs. c-Myc overexpression is associated with lymph node metastasis in pNET xenograft mice. Combinational treatment of mTOR inhibitor with c-Myc inhibitor or VEGFC neutralizing chimera protein reduced lymph node metastasis of the mice with c-Myc overexpression. mTOR inhibitor acts on lymphangiogenesis via reducing VEGFC expression in pNET cells and inhibiting tube formation of LECs. In conclusion, mTOR and c-Myc are important for lymphangiogenesis of pNET and are potential therapeutic targets for prevention and treatment of lymph node metastasis in pNET.
    日期: 2021-01
    關聯: Cancer Science. 2021 Jan;112(1):243-253.
    Link to: http://dx.doi.org/10.1111/cas.14717
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1347-9032&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000591671200001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85097006001
    顯示於類別:[蔡慧珍] 期刊論文
    [陳立宗] 期刊論文
    [張書銘] 期刊論文
    [洪文俊] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB33128283.pdf974KbAdobe PDF320檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋