Gut microbiome has been associated with many human disorders and conditions such as allergy, obesity, inflammatory bowel disease and various types of cancers. Many of these diseases have become important health issues worldwide and effective strategies for their treatment and/or prevention are highly desired. We previously have found that dual‐specificity phosphatase 6 (Dusp6)‐deficient mice had reduced body weight gain and alleviated metabolic disorders. Notably, 16S rRNA gene sequencing revealed that the gut/fecal microbiota in Dusp6‐deficient mice was more resistant to high‐fat‐diet‐ induced dysbiosis compared with wild‐type mice. The RNA‐seq gut transcriptome analysis has shown several potential mechanisms driving the microbiota alteration in Dusp6‐deficient mice. We also found that Dusp6 knockout mice compared with wild‐type littermate mice were more resistant to dextran sulfate sodium (DSS)‐induced colitis and the mechanisms of the Dusp6 deficiency in shaping gut microbiome and barrier integrity were investigated. In summary, these findings indicate that Dusp6‐deficiency is a novel host genetic factor that could modulate gut barrier and inhibiting DUSP6 might be a novel strategy to maintain gut microbiome eubiosis.
Date:
2020-04
Relation:
FASEB Journal. 2020 Apr;34(S1):Abstract number 09605.
