國家衛生研究院 NHRI:Item 3990099045/12764
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12764


    Title: Genetic variants in NECTIN4 encoding an adhesion molecule are associated with continued opioid use
    Authors: Fang, CP;Liu, TH;Chung, RH;Tsou, HH;Kuo, HW;Wang, SC;Liu, CC;Liu, SC;Chen, ACH;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Institute of Population Health Sciences
    Abstract: Methadone is a synthetic opioid used as maintenance treatment for patients addicted to heroin. Skin irritation is one of the adverse events caused by opioid use. 344 methadone maintenance treatment (MMT) patients were recruited with records and measurements on methadone dose, plasma methadone concentrations, and treatment emergent symptom scales (TESS). 15 patients reported with skin irritation. Five SNPs located within the NECTIN4 genetic region were genotyped. The NECTIN4 gene within the adherens junction interaction pathway was associated with methadone dose in pathway-based genome wide association analyses (P = 0.0008). Three highly-linked SNPs, rs11265549, rs3820097, and rs4656978, were significantly associated with methadone dose (P = 0.0003), plasma concentrations of R,S-methadone (P = 0.0004) and TNF-α (P = 0.010) in all 344 MMT patients, and with self-report skin irritation symptom scores (P = 0.010) in the 15 MMT patients who reported with skin irritation. To identify the possible roles of plasma level of Nectin-4 in the responses to MMT and opioid use, additional age- and gender-matched 51 controls and 83 methadone-free abstinent former heroin users were recruited. Plasma level of Nectin-4 was the highest in MMT patients among the three groups. The results suggest involvement of genetic variants on NECTIN4 in methadone dose. Plasma Nectin-4 level is likely an indicator for continued use of opioids.
    Date: 2020-06-18
    Relation: PLoS ONE. 2020 Jun 18;15(6):Article number e0234549.
    Link to: http://dx.doi.org/10.1371/journal.pone.0234549
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1932-6203&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000543273200079
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85086729511
    Appears in Collections:[Yu-Li Liu] Periodical Articles
    [Sheng-Chang Wang] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles
    [Ren-Hua Chung] Periodical Articles

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