Asians with predisposition for diabetes mellitus (DM) contributed to over 60% of the world’s diabetic population. DM model has been widely applied in assisting healthcare decision. Only few studies comparing validity of DM models developing from different races for Asian DM population. We examined model validity of United Kingdom Prospective Diabetes Study (UKPDS) Outcomes and Taiwan Diabetes Mellitus Hoslistic Care (TwDM) models against major complications of Taiwan type 2 DM population.