國家衛生研究院 NHRI:Item 3990099045/12709
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    题名: Lung-specific regulation of angiotensin system by chronic exposure of particulate matter
    作者: Chuang, HC;Chen, YY;Chen, JK;Hsiao, TC;Cheng, TJ
    贡献者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Background: Effects of air pollution on pulmonary toxicity have been reported. The objective of this study was to investigate the regulation of angiotensin system caused by particulate matter (PM) in lungs. We examined the effects of traffic‐related particulate matter with an aerodynamic diameter of <1 μm (PM1), high‐efficiency particulate air (HEPA)‐filtered air, and clean air on the underlying pathways of angiotensin system in lungs after 3 and 6 months of whole‐body exposure in 6‐month‐old Sprague Dawley rats.Results: The rats were exposed to 16.3 ± 8.2 (4.7~68.8) μg/m3 of PM1 during the study period. We observed that angiotensin‐converting enzyme (ACE) was significantly decreased with 6 months of PM1 exposure. Angiotensin II (AngII) was significantly increased after 3‐months exposure of PM1. Angiotensin type 1 (AT1) receptor was significantly decreased with 6 months of PM1 exposure; however, we did not observed significant change in angiotensin type 2 (AT2) receptor or AT1/AT2 ratio in lung tissue after exposure. RAS was activated by 3‐months exposure of PM1 in lung. Conclusions: Our results suggest the pathways related to angiotensin system may be
    日期: 2019-11
    關聯: Respirology. 2019 Nov;24:121-122.
    Link to: http://dx.doi.org/10.1111/resp.13700_76
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1323-7799&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000531157100279
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