國家衛生研究院 NHRI:Item 3990099045/12701
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    题名: A survival prediction nomogram for liposomal irinotecan (nal-IRI)+5-fluorouracil/leucovorin (5-FU/LV) in patients (pts) with metastatic pancreatic ductal adenocarcinoma (mPDAC) previously treated with gemcitabine-based therapy
    作者: Wang-Gillam, A;Hubner, R;Mirakhur, B;de Jong, F;Belanger, B;Chen, LT
    贡献者: National Institute of Cancer Research
    摘要: Background: NAPOLI-1 (NCT01494506) was a global phase 3 study in pts with mPDAC previously treated with gemcitabine-based therapy that showed a significant improvement in overall survival (OS) in pts treated with nal-IRI+5-FU/LV vs 5-FU/LV alone. A nomogram assists in predicting individualized risk for prespecified events, such as OS, death, or adverse events. A post hoc analysis of NAPOLI-1 was conducted to develop a nomogram to predict OS for nal-IRI+5-FU/LV in the post-gemcitabine setting. Methods: In NAPOLI-1, pts received nal-IRI+5-FU/LV, nal-IRI, or 5-FU/LV. Univariate and multivariate analyses identified baseline factors that were significantly predictive of OS. A multivariable Cox regression model was created to develop a nomogram that assigned points equal to the weighted sum of relative significance of each variable. The predictive accuracy of the nomogram, as measured by the concordance index (c-index), was evaluated by internal bootstrap validation. Results: Data from pts in the univariate analysis (n = 417) and multivariate analysis (n = 399; n = 18 pts excluded for missing data) were used. Eight of 21 variables were retained in the multivariate analysis and re-tested through stratification (all factors significant at the P < 0.01 level, except BMI [P= 0.08]). Conclusions: Key predictors of OS in NAPOLI-1 were nal-IRI+5-FU/LV treatment, KPS, NLR, albumin level, baseline CA19-9, stage 4 at diagnosis, BMI, and presence of liver metastasis.
    日期: 2018-05
    關聯: Journal of Clinical Oncology. 2018 May;36(15, Suppl.):Meeting Abstract e16204.
    Link to: http://dx.doi.org/10.1200/JCO.2018.36.15_suppl.e16204
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0732-183X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000442916005318
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