國家衛生研究院 NHRI:Item 3990099045/12661

NHRI > National Institute of Infectious Diseases and Vaccinology > Shu-Chen Kuo > Periodical Articles > Item 3990099045/12661

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12661

Title:	Plasmid- and chromosome-located mcr-3 in mcr-1-positive Escherichia coli in Taiwan
Authors:	Hsu, CY;Chen, FJ;Huang, WC;Liao, YC;Lauderdale, TL;Kuo, SC
Contributors:	National Institute of Infectious Diseases and Vaccinology;Institute of Population Health Sciences
Abstract:	The mobile colistin resistance gene, mcr-1, and its variants have been detected among humans and domestic animals worldwide. Since its first detection in 2017, mcr-3 has been reported in Asia, Europe and North America. Here, we describe the presence of mcr-3 in diverse plasmids and the chromosome in Escherichia coli from diseased swine, and the co-occurrence of plasmid-located mcr-1. E. coli isolates from humans, retail meat, and diseased swine (n= 7942, 537, and 645, respectively) were subjected to reference broth microdilution method. A part of human and meat isolates have been published for the prevalence of mcr-1 [1] (please see Supplementary methods for the details). PCR targeting mcr-1 to mcr-8 was performed on colistin-resistant isolates. Only mcr-1 was detected in 58 and 41 isolates from humans and meat, respectively. Among isolates from diseased swine, 330 were positive for mcr-1 only, seven were positive for mcr-3 only and three were concomitantly positive for mcr-1 and mcr-3. The 10 mcr-3-positive isolates were multi-drug resistant but the co-occurrence of mcr-1 and mcr-3 did not increase colistin MICs (Supplementary Table S1).
Date:	2020-07
Relation:	International Journal of Antimicrobial Agents. 2020 Jul;56(1):Article number 105996.
Link to:	http://dx.doi.org/10.1016/j.ijantimicag.2020.105996
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000552613500040
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085350977
Appears in Collections:	[Shu-Chen Kuo] Periodical Articles [Tsai-Ling Yang Lauderdale] Periodical Articles [Feng-Jui Chen] Periodical Articles [Yu-Chieh Liao] Periodical Articles

Files in This Item:

File	Description	Size	Format
PUB32335277.pdf		1141Kb	Adobe PDF	254	View/Open

Loading...