國家衛生研究院 NHRI:Item 3990099045/12624
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12189/12972 (94%)
造訪人次 : 967283      線上人數 : 903
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12624


    題名: Multicentre study of risk factors for mortality in patients with acinetobacter bacteraemia receiving colistin treatment
    作者: Lee, YT;Sun, JR;Wang, YC;Chiu, CH;Kuo, SC;Chen, TL;Yang, YS
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: Colistin remains a last-line antibiotic for the treatment of multi-drug-resistant Acinetobacter species. However, mortality rates are high in patients with Acinetobacter infection receiving colistin treatment. This multi-center study evaluated whether colistin susceptibility, additional antimicrobial agents, or other prognostic factors influenced the clinical outcomes of patients receiving colistin treatment for Acinetobacter bacteremia. This retrospective study enrolled 122 adults receiving colistin treatment for monomicrobial Acinetobacter bacteremia at six medical centers over 8 years. Clinical information, antimicrobial susceptibility, and colistin resistance determinants were analysed. The primary outcome measure was 14-day mortality. Among 122 patients, 18 and 104 were infected with colistin-resistant (ColR) isolates (minimal inhibitory concentrations [MICs] >/=4 mg/L) and colistin-susceptible (ColS) isolates (MICs </=2 mg/L), respectively. Patients infected with ColR and ColS isolates were not significantly different in Charlson comorbidity index, invasive procedures, sources of bacteremia, disease severity, and 14-day mortality rates (44.4% vs. 34.6%, P=0.592). No specific additional antimicrobial agent was independently associated with higher or lower mortality. Coronary artery disease, higher APACHE II score, and bacteremia caused by A. baumannii were independent risk factors associated with 14-day mortality. The mechanisms of colistin resistance were associated with amino acid variants in the pmrCAB operon. Finally, we identified previously unreported A. nosocomialis amino acid variants related to colistin resistance. In conclusion, colistin susceptibility and colistin combination antimicrobial treatment were not associated with decreased 14-day mortality in patients with Acinetobacter bacteremia receiving colistin treatment.
    日期: 2020-06
    關聯: International Journal of Antimicrobial Agents. 2020 Jun;55(6):Article number 105956.
    Link to: http://dx.doi.org/10.1016/j.ijantimicag.2020.105956
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0924-8579&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000545310600010
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085105150
    顯示於類別:[郭書辰] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB32278810.pdf589KbAdobe PDF212檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋