國家衛生研究院 NHRI:Item 3990099045/12601

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Title:	High-intensity focused ultrasound ablation combined with electrical passive exercise for fast removal of body fat
Authors:	Tan, JS;Lin, CC;Cheng, JS;Chen, GS
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	BACKGROUND: High-intensity focused ultrasound (HIFU) lipolysis still lacks treatment efficacy. We hypothesized that electrical stimulation (ES) of muscular groups can enhance the metabolism of free lipids released from HIFU-ablated adipocytes. METHODS: Five-month-old, male Landrace swine, 95 kg average initial weight, were randomly divided into sham, HIFU-only, HIFU+ES I and HIFU+ES II groups. Subcutaneous adipose tissue of the porcine abdomen was treated once by HIFU on the 1 day of the 1, 3 and 5 weeks, and electrical stimulation of the quadriceps was performed once on the 1 day of the 1 to 6 weeks. The numbers of ultrasonic sonications were 70 per treatment for the HIFU-only and HIFU+ES I groups and 400 for the HIFU+ES II group. The measured data are expressed as medians (ranges). RESULTS: The body weights of all pigs increased gradually with time. The waist circumferences below the sheath decreased from 97.7(6.0) cm in the 1 week, 97.9(5.3) cm in the 3 week to 96.4(10.0) cm in the 6 week and from 105.3(5.1) cm, 101.2(7.4) cm to 100.5(6.1) cm for the HIFU+ES I and HIFU+ES II groups, respectively, whereas they increased for the sham and HIFU-only groups. The reductions in the adipose tissue thickness were 0.59, 1.46 and 2.18 mm for the HIFU-only, HIFU+ES I and HIFU+ES II groups, respectively, when the sham group increased by 1.42 mm. Follow-up blood analyses demonstrated no significant changes in lipid panel parameters from baseline values. CONCLUSIONS: HIFU-electrical therapy can induce a substantial reduction in the waist circumference of pigs.
Date:	2020-06
Relation:	Plastic and Reconstructive Surgery. 2020 Jun;145(6):1427-1438.
Link to:	http://dx.doi.org/10.1097/prs.0000000000006826
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0032-1052&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000537866300039
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85085630347
Appears in Collections:	[Gin-Shin Chen] Periodical Articles

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