國家衛生研究院 NHRI:Item 3990099045/12589
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12589


    Title: Role of microtubule-associated protein 1b in urothelial carcinoma: Overexpression predicts poor prognosis
    Authors: Chien, TM;Chan, TC;Huang, SK;Yeh, BW;Li, WM;Huang, CN;Li, CC;Wu, WJ;Li, CF
    Contributors: National Institute of Cancer Research
    Abstract: We sought to examine the relationship between microtubule-associated proteins (MAPs) and the prognosis of urothelial carcinoma by assessing the microtubule bundle formation genes using a reappraisal transcriptome dataset of urothelial carcinoma (GSE31684). The result revealed that microtubule-associated protein 1b (MAP1B) is the most significant upregulated gene related to cancer progression. Real-time reverse-transcription polymerase chain reaction was used to measure MAP1B transcription levels in urothelial carcinoma of the upper tract (UTUC) and the bladder (UBUC). Immunohistochemistry was conducted to detect MAP1B protein expression in 340 UTUC and 295 UBUC cases. Correlations of MAP1B expression with clinicopathological status, disease-specific survival, and metastasis-free survival were completed. To assess the oncogenic functions of MAP1B, the RTCC1 and J82 cell lines were stably silenced against their endogenous MAP1B expression. Study findings indicated that MAP1B overexpression was associated with adverse clinical features and could independently predict unfavorable prognostic effects, indicating its theranostic value in urothelial carcinoma.
    Date: 2020-03-09
    Relation: Cancers. 2020 Mar 9;12(3):Article number 630.
    Link to: http://dx.doi.org/10.3390/cancers12030630
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2072-6694&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000530232300106
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082564048
    Appears in Collections:[Others] Periodical Articles

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