國家衛生研究院 NHRI:Item 3990099045/12561
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    题名: Seroprevalence of EV-A71 neutralizing antibodies following the 2011 epidemic in HCMC, Vietnam
    作者: Kuo, FL;Khanh, TH;Chung, WY;Hung, NT;Luo, ST;Chang, WC;Nhan, LNT;Thinh, LQ;Lee, MS
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Enterovirus-A71 (EV-A71) cyclically causes hand-foot-mouth disease (HFMD) epidemics in Asian children. An EV-A71 epidemic occurred in Southern Vietnam in 2011, but its scale is not clear. We collected residual sera from non-HFMD Vietnamese inpatients in 2012-2013 to determine seroprevalence of EV-A71 neutralizing antibodies, and measured cross-reactive neutralizing antibody titers against three EV-A71 genogroups. About 23.5% of 1-year-old children in Southern Vietnam has been infected by EV-A71, and the median age of infection was estimated to be 3 years. No significant antigenic variation could be detected among the three EV-A71 genogroups. The high seroprevalence of EV-A71 neutralizing antibody in children living in southern Vietnam indicates the necessity of introducing EV-A71 vaccines in southern Vietnam, particularly for children under 6 months of age. Moreover, it is critical to understand EV-A71 disease burden for formulating national vaccination policy.
    日期: 2020-03
    關聯: PLoS Neglected Tropical Diseases. 2020 Mar;14(3):Article number e0008124.
    Link to: http://dx.doi.org/10.1371/journal.pntd.0008124
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1935-2735&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000528655400064
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85082098245
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