國家衛生研究院 NHRI:Item 3990099045/12547
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    题名: WNT3A promotes neuronal regeneration upon traumatic brain injury
    作者: Chang, CY;Liang, MZ;Wu, CC;Huang, PY;Chen, HI;Yet, SF;Tsai, JW;Kao, CF;Chen, L
    贡献者: Institute of Cellular and Systems Medicine
    摘要: The treatment of traumatic brain injury (TBI) remains a challenge due to limited knowledge about the mechanisms underlying neuronal regeneration. This current study compared the expression of WNT genes during regeneration of injured cortical neurons. Recombinant WNT3A showed positive effect in promoting neuronal regeneration via in vitro, ex vivo, and in vivo TBI models. Intranasal administration of WNT3A protein to TBI mice increased the number of NeuN(+) neurons without affecting GFAP(+) glial cells, compared to control mice, as well as retained motor function based on functional behavior analysis. Our findings demonstrated that WNT3A, 8A, 9B, and 10A promote regeneration of injured cortical neurons. Among these WNTs, WNT3A showed the most promising regenerative potential in vivo, ex vivo, and in vitro.
    日期: 2020-02-21
    關聯: International Journal of Molecular Sciences. 2020 Feb 21;21(4):Article number 1463.
    Link to: http://dx.doi.org/10.3390/ijms21041463
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1422-0067&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000522524400290
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85079889683
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