Loading...
|
Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/12505
|
| Title: | The presence of ectopic atrial rhythm predicts adverse cardiovascular outcomes in a large hospital-based population |
| Authors: | Huang, SH;Hu, YF;Chen, PF;Lin, YJ;Chang, SL;Lo, LW;Chung, FP;Tuan, TC;Chao, TF;Liao, JN;Chang, TY;Lin, CY;Liu, CM;Huang, TC;Vicera, JJB;Lee, PT;Lugtu, IC;Jain, A;Wu, IC;Chen, SA |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | BACKGROUND: Whether ectopic atrial rhythm (EAR) is a high-risk cardiovascular phenotype (e.g., the manifestation of a diseased sinoatrial node) or just a benign accelerated ectopic pacemaker remains unclear. OBJECTIVE: We aimed to analyze the cardiovascular outcomes and underlying mechanisms in patients with EAR. METHODS: From a 12-lead electrocardiogram (ECG) hospital-based ECG database, a total of 2896 adults with EAR were propensity-matched at 1:5 with 14480 subjects with sinus rhythm (SR). The patients were retrospectively followed up for cardiovascular mortality (the primary outcome) and permanent pacemaker implantation (the secondary outcome). Heart rate variability (HRV) was analyzed to compare autonomic function between patients with EAR and SR. RESULTS: The prevalence of EAR was 1.13%, which increased with age. Compared with the matched patients, those with EAR had higher risk of cardiovascular mortality [adjusted hazard ratio (HR): 1.93, 95% confidence interval (CI): 1.52-2.44, P < 0.0001) and permanent pacemaker implantation (adjusted HR: 5.94, 95% CI: 3.89-9.09, P < 0.0001) according to the Cox proportional hazards regression model. The risk of cardiovascular mortality was similar across subgroups based on age, sex, hypertension, type 2 diabetes mellitus, congestive heart failure, myocardial infarction, stroke, and chronic kidney diseases. In patients with EAR, the ratio of low frequency/high frequency and standard deviation of the average normal-to-normal/root mean square of successive differences for HRV were both lower than those in patients with SR. This implied autonomic imbalance in patients with EAR. CONCLUSION: Patients with EAR increased risk of cardiovascular mortality and permanent pacemaker implantation, associated with the autonomic imbalance. |
| Date: | 2020-06 |
| Relation: | Heart Rhythm. 2020 Jun;17(6):967-974. |
| Link to: | http://dx.doi.org/10.1016/j.hrthm.2020.01.024 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1547-5271&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000538410600010 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85084649730 |
| Appears in Collections: | [吳易謙] 期刊論文
|
Files in This Item:
| File |
Description |
Size | Format | |
|---|
| PUB32028045.pdf | | 1992Kb | Adobe PDF | 407 | View/Open |
|
All items in NHRI are protected by copyright, with all rights reserved.
|
