國家衛生研究院 NHRI:Item 3990099045/12496
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    题名: Proton-pump inhibitors augment the risk of major adverse cardiovascular events and end-stage renal disease in patients with acute kidney injury after temporary dialysis
    作者: Tsai, IJ;Lai, TS;Shiao, CC;Huang, TM;Wang, CH;Chen, LW;Lin, YH;Chen, L;Wu, VC;Chu, TS
    贡献者: Institute of Population Health Sciences
    摘要: Proton-pump inhibitors (PPIs) have been reported to increase the risk of acute and chronic renal disease. However, the data is unclear in patients with acute kidney injury (AKI) requiring dialysis (AKI-D) who are often candidates for PPI. To investigate this important issue, we identified 26,052 patients from Taiwan's National Health Insurance Research Database weaning dialysis from AKI-D. During a mean follow-up period of 3.52 years, the PPI users had a higher incidence of end-stage renal disease (ESRD) than the PPI non-users (P<.001). After propensity score matching and treating mortality as a competing risk factor, the PPIs users had a higher risk in ESRD (sHR 1.40; 95% CI 1.31-1.50) and major adverse cardiac events (MACE, sHR1.53; 95 %CI 1.37-1.71) compared to the PPI non-users with AKI-D survivors. In conclusion, the use of PPIs was associated with a higher risk of ESRD and MACE, compared to the PPI non-users in AKI-D patients.
    日期: 2020-06
    關聯: Clinical Pharmacology and Therapeutics. 2020 Jun;107(6):1434-1445.
    Link to: http://dx.doi.org/10.1002/cpt.1762
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0009-9236&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000531679700019
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85081254397
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