國家衛生研究院 NHRI:Item 3990099045/12493

NHRI > National Institute of Infectious Diseases and Vaccinology > Chun-Hong Chen > Periodical Articles > Item 3990099045/12493

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12493

Title:	Broad dengue neutralization in mosquitoes expressing an engineered antibody
Authors:	Buchman, A;Gamez, S;Li, M;Antoshechkin, I;Li, HH;Wang, HW;Chen, CH;Klein, MJ;Duchemin, JB;Crowe, JE, Jr.;Paradkar, PN;Akbari, OS
Contributors:	National Institute of Infectious Diseases and Vaccinology;National Mosquito-Borne Diseases Control Research Center
Abstract:	With dengue virus (DENV) becoming endemic in tropical and subtropical regions worldwide, there is a pressing global demand for effective strategies to control the mosquitoes that spread this disease. Recent advances in genetic engineering technologies have made it possible to create mosquitoes with reduced vector competence, limiting their ability to acquire and transmit pathogens. Here we describe the development of Aedes aegypti mosquitoes synthetically engineered to impede vector competence to DENV. These mosquitoes express a gene encoding an engineered single-chain variable fragment derived from a broadly neutralizing DENV human monoclonal antibody and have significantly reduced viral infection, dissemination, and transmission rates for all four major antigenically distinct DENV serotypes. Importantly, this is the first engineered approach that targets all DENV serotypes, which is crucial for effective disease suppression. These results provide a compelling route for developing effective genetic-based DENV control strategies, which could be extended to curtail other arboviruses.
Date:	2020-01
Relation:	PLoS Pathogens. 2020 Jan;16(1):Article number e1008103.
Link to:	http://dx.doi.org/10.1371/journal.ppat.1008103
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1553-7366&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000510746400037
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078073414
Appears in Collections:	[Chun-Hong Chen] Periodical Articles [Others] Periodical Articles

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