國家衛生研究院 NHRI:Item 3990099045/12476
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12476


    Title: Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence
    Authors: Fang, CP;Wang, SC;Tsou, HH;Chung, RH;Hsu, YT;Liu, SC;Kuo, HW;Liu, TH;Chen, ACH;Liu, YL
    Contributors: Center for Neuropsychiatric Research;Institute of Population Health Sciences
    Abstract: Delta opioid receptor (DOR) is well known to be involved in heroin dependence. This study tested the hypothesis that single nucleotide polymorphisms (SNPs) in the opioid receptor delta 1 (OPRD1) gene coding region are associated with treatment responses in a methadone maintenance therapy (MMT) cohort in Taiwan. Three hundred forty-four MMT patients were recruited. Diastolic/systolic blood pressure, heart rate, methadone dosage, and plasma concentrations of methadone were recorded. Twenty-five SNPs located within the OPRD1 genetic region were selected and genotyped from the genomic DNA of all 344 participants. After pairwise tagger analyses, tagger SNP rs204047 showed a significant association with methadone dosage (P = 0.0019), and tagger SNPs rs204047 and rs797397 were significantly associated with plasma R, S-methadone concentrations (P < 0.0006) in patients tested negative in the urine morphine test, which indicated patients with a better response to MMT. The major genotype carriers showed a higher methadone dosage and higher plasma concentrations of R, S-methadone than the minor genotype carriers. The results indicated that OPRD1 genetic variants were associated with methadone dosage and methadone plasma concentration in MMT patients with a negative morphine test result.
    Date: 2020-04
    Relation: Journal of Human Genetics. 2020 Apr;65:381-386.
    Link to: http://dx.doi.org/10.1038/s10038-019-0718-x
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1434-5161&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000508155400003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077586522
    Appears in Collections:[Yu-Li Liu] Periodical Articles
    [Sheng-Chang Wang] Periodical Articles
    [Ren-Hua Chung] Periodical Articles
    [Hsiao-Hui Sophie Tsou] Periodical Articles

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