國家衛生研究院 NHRI:Item 3990099045/12460
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    题名: A mosquito salivary protein promotes flavivirus transmission by activation of autophagy
    作者: Sun, P;Nie, K;Zhu, Y;Liu, Y;Wu, P;Liu, Z;Du, S;Fan, H;Chen, CH;Zhang, R;Wang, P;Cheng, G
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: Transmission from an infected mosquito to a host is an essential process in the life cycle of mosquito-borne flaviviruses. Numerous studies have demonstrated that mosquito saliva facilitates viral transmission. Here we find that a saliva-specific protein, named Aedes aegypti venom allergen-1 (AaVA-1), promotes dengue and Zika virus transmission by activating autophagy in host immune cells of the monocyte lineage. The AG6 mice (ifnar1(-/-)ifngr1(-/-)) bitten by the virus-infected AaVA-1-deficient mosquitoes present a lower viremia and prolonged survival. AaVA-1 intracellularly interacts with a dominant negative binder of Beclin-1, known as leucine-rich pentatricopeptide repeat-containing protein (LRPPRC), and releases Beclin-1 from LRPPRC-mediated sequestration, thereby enabling the initialization of downstream autophagic signaling. A deficiency in Beclin-1 reduces viral infection in mice and abolishes AaVA-1-mediated enhancement of ZIKV transmission by mosquitoes. Our study provides a mechanistic insight into saliva-aided viral transmission and could offer a potential prophylactic target for reducing flavivirus transmission.
    日期: 2020-01-14
    關聯: Nature Communications. 2020 Jan 14;11:Article number 260.
    Link to: http://dx.doi.org/10.1038/s41467-019-14115-z
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000528903400003
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077872547
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