國家衛生研究院 NHRI:Item 3990099045/12452
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    题名: Generation of induced pluripotent stem cells MMCi001-A from a Taiwanese hearing loss patient carrying GJB2 pV37I mutation
    作者: Lu, HE;Tsai, CL;Chiu, IM;Pan, YL;Lin, YF;Lin, HC;Hsu, YC
    贡献者: Institute of Cellular and Systems Medicine
    摘要: Hearing loss is the most common disorder in the sensory system. Mutations in GJB2 have been reported to be very common in sensorineural hearing loss patients. In this report, we generated an induced pluripotent stem cell (iPSC) line, MMCi001-A, from the peripheral blood mononuclear cells of a 4-year-old male hearing loss patient carrying GJB2 pV37I mutation by using the Sendai virus delivery system. The generated iPSCs were demonstrated to express pluripotent markers and be differentiated into three germ layers in vitro and in vivo. This GJB2-pV37I iPSCs is valuable for studying the pathogenic mechanisms and drug discovery of hearing loss.
    日期: 2019-12-18
    關聯: Stem Cell Research. 2019 Dec 18;42:Article number 101692.
    Link to: http://dx.doi.org/10.1016/j.scr.2019.101692
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1873-5061&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000522733200024
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85077070382
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