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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12390


    Title: Phthalate exposure and prostate cancer in a population-based nested case-control study
    Authors: Chuang, SC;Chen, HC;Sun, CW;Chen, YA;Wang, YH;Chiang, CJ;Chen, CC;Wang, SL;Chen, CJ;Hsiung, CA
    Contributors: Institute of Population Health Sciences;National Institute of Environmental Health Sciences
    Abstract: BACKGROUND: Phthalic acid esters are established as endocrine disruptors. The study aimed to evaluate the association between urinary phthalate metabolites and prostate cancer occurrence. METHODS: The study was based on the Taiwan Community-Based Cancer Screening Program, which was set up in 1991-1992 and followed periodically. By 2010, 80 incident prostate cancer cases were identified in the 12,020 men. For each case, 2 controls were randomly selected, matched by age (+/-3 years), urine collection date (+/-3 months), and residential township. Frequently used phthalate metabolites from the urine samples were quantified by liquid chromatography/electrospray ionization tandem mass spectrometry. Logistic regression was conducted to assess the association between the exposure levels and prostate cancer occurrence. RESULTS: Exposure to di (2-ethylhexyl), butyl-benzyl and di-isobutyl phthalates (DEHP, BBzP, DiBP) was positively associated with prostate cancer in men with waist circumference (WC) >/=90cm but not in the leans. Odds ratio for the DEHP metabolite summary score (upper tertile compared to the rest) and prostate cancer were 7.76 (95% CI=1.95-30.9) for WC>/=90cm. CONCLUSIONS: DEHP, BBzP, and DiBP exposure were associated with prostate cancer occurrence in abdominally obese men. The main limitation remains the lack of mechanistic experiments and comparable toxicological data.
    Date: 2020-02
    Relation: Environmental Research. 2020 Feb;181:Article number 108902.
    Link to: http://dx.doi.org/10.1016/j.envres.2019.108902
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0013-9351&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000510109700030
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85078372450
    Appears in Collections:[熊昭] 期刊論文
    [陳主智] 期刊論文
    [莊淑鈞] 期刊論文
    [王淑麗] 期刊論文

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