國家衛生研究院 NHRI:Item 3990099045/12355

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Title:	Neurodegenerative diseases associated with mitochondrial DNA mutations
Authors:	Zhunina, OA;Yabbarov, NG;Grechko, AV;Yet, SF;Sobenin, IA;Orekhov, AN
Contributors:	Institute of Cellular and Systems Medicine
Abstract:	Mitochondrial dysfunction underlies several human chronic pathologies, including cardiovascular disorders, cancers and neurodegenerative diseases. Impaired mitochondrial function associated with oxidative stress can be a result of both nuclear and mitochondrial DNA (mtDNA) mutations. Neurological disorders associated with mtDNA mutations include mitochondrial encephalomyopathy, chronic progressive external ophthalmoplegia, neurogenic weakness, and Leigh syndrome. Moreover, mtDNA mutations were shown to play a role in the development of Parkinson and Alzheimer's diseases. In this review, the discuss the current knowledge on the distribution and possible roles of mtDNA mutations in the onset and development of various neurodegenerative diseases, with special focus on Parkinson and Alzheimer's diseases.
Date:	2020-01
Relation:	Current Pharmaceutical Design. 2020 Jan;26(1):103-109.
Link to:	http://dx.doi.org/10.2174/1381612825666191122091320
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1381-6128&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000517755600008
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85081109253
Appears in Collections:	[Shaw-Fang Yet] Periodical Articles

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