國家衛生研究院 NHRI:Item 3990099045/12325
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    題名: Associations of autozygosity with a broad range of human phenotypes
    作者: Clark, DW;Okada, Y;Moore, KHS;Mason, D;Pirastu, N;Gandin, I;Mattsson, H;Barnes, CLK;Lin, K;Zhao, JH;Deelen, P;Rohde, R;Schurmann, C;Guo, X;Giulianini, F;Zhang, W;Medina-Gomez, C;Karlsson, R;Bao, Y;Bartz, TM;Baumbach, C;Biino, G;Bixley, MJ;Brumat, M;Chai, JF;Corre, T;Cousminer, DL;Dekker, AM;Eccles, DA;van Eijk, KR;Fuchsberger, C;Gao, H;Germain, M;Gordon, SD;de Haan, HG;Harris, SE;Hofer, E;Huerta-Chagoya, A;Igartua, C;Jansen, IE;Jia, Y;Kacprowski, T;Karlsson, T;Kleber, ME;Li, SA;Li-Gao, R;Mahajan, A;Matsuda, K;Meidtner, K;Meng, W;Montasser, ME;van der Most, PJ;Munz, M;Nutile, T;Palviainen, T;Prasad, G;Prasad, RB;Priyanka, TDS;Rizzi, F;Salvi, E;Sapkota, BR;Shriner, D;Skotte, L;Smart, MC;Smith, AV;van der Spek, A;Spracklen, CN;Strawbridge, RJ;Tajuddin, SM;Trompet, S;Turman, C;Verweij, N;Viberti, C;Wang, L;Warren, HR;Wootton, RE;Yanek, LR;Yao, J;Yousri, NA;Zhao, W;Adeyemo, AA;Afaq, S;Aguilar-Salinas, CA;Akiyama, M;Albert, ML;Allison, MA;Alver, M;Aung, T;Azizi, F;Bentley, AR;Boeing, H;Boerwinkle, E;Borja, JB;de Borst, GJ;Bottinger, EP;Broer, L;Campbell, H;Chanock, S;Chee, ML;Chen, G, .;et al.
    貢獻者: Institute of Population Health Sciences
    摘要: In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: FROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of FROH are confirmed within full-sibling pairs, where the variation in FROH is independent of all environmental confounding.
    日期: 2019-10-31
    關聯: Nature Communications. 2019 Oct 31;10:Article number 4957.
    Link to: http://dx.doi.org/10.1038/s41467-019-12283-6
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2041-1723&DestApp=IC2JCR
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85074297784
    顯示於類別:[邱燕楓] 期刊論文
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