國家衛生研究院 NHRI:Item 3990099045/12314
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    题名: Investigation the roles of IL-12 family cytokines on the thymic T cell selection and the subsequent impact on peripheral T cell pool
    作者: Chou, FC;Chen, HY;Sytwu, HK
    贡献者: National Institute of Infectious Diseases and Vaccinology
    摘要: IL-12 family cytokines play crucial roles in T cell immune responses in the peripheral which regulate the inflammatory and tolerance. Interestingly, previous reports have demonstrated that IL-12 and IL-23 have supportive effect in the thymic negative selection and regulatory T cell generation. However, their roles in the TCR repertoire diversity and subsequent effect on the peripheral immunity is unclear. In this study, we used IL-12p35 knockout and IL-23p19 knockdown NOD mouse model to address this issue. We first found increased thymocyte numbers in IL-12p35 knockout and IL-23p19 knockdown NOD mouse. Then we used thymus transplantation and bone marrow chimera model to investigate the effects of these cytokine on TCR repertoire distribution and autoimmune phenotype. The NOD-RAG1 -/- mice which received IL-23p19 knockdown thymus displayed increased susceptibility to autoimmunity. Interestingly, T cells derived from IL-12p35 knockout thymus showed increased IFN-g and decreased IL-17 production in peripheral and inflammatory lesion. Our data suggested that IL-12 and IL-23 have supportive role in the central tolerance and defect of these cytokines in the thymus could leads to autoimmunity.
    日期: 2019-10
    關聯: European Journal of Immunology. 2019 Oct;49(S3):377.
    Link to: https://doi.org/10.1002/eji.201970400
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0014-2980&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000490026901148
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