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Please use this identifier to cite or link to this item:
http://ir.nhri.org.tw/handle/3990099045/12308
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| Title: | Inhibition of miR-21 alleviated cardiac perivascular fibrosis via repressing EndMT in T1DM |
| Authors: | Li, QQ;Yao, YF;Shi, SM;Zhou, MC;Zhou, YC;Wang, MR;Chiu, EJ;Huang, ZR;Zhang, WL;Liu, M;Wang, Q;Tu, X |
| Contributors: | Institute of Cellular and Systems Medicine |
| Abstract: | In type 1 and type 2 diabetes mellitus, increased cardiac fibrosis, stiffness and associated diastolic dysfunction may be the earliest pathological phenomena in diabetic cardiomyopathy. Endothelial-mesenchymal transition (EndMT) in endothelia cells (ECs) is a critical cellular phenomenon that increases cardiac fibroblasts (CFs) and cardiac fibrosis in diabetic hearts. The purpose of this paper is to explore the molecular mechanism of miR-21 regulating EndMT and cardiac perivascular fibrosis in diabetic cardiomyopathy. In vivo, hyperglycaemia up-regulated the mRNA level of miR-21, aggravated cardiac dysfunction and collagen deposition. The condition was recovered by inhibition of miR-21 following with improving cardiac function and decreasing collagen deposition. miR-21 inhibition decreased cardiac perivascular fibrosis by suppressing EndMT and up-regulating SMAD7 whereas activating p-SMAD2 and p-SMAD3. In vitro, high glucose (HG) up-regulated miR-21 and induced EndMT in ECs, which was decreased by inhibition of miR-21. A highly conserved binding site of NF-kappa B located in miR-21 5 '-UTR was identified. In ECs, SMAD7 is directly regulated by miR-21. In conclusion, the pathway of NF-kappa B/miR-21/SMAD7 regulated the process of EndMT in T1DM, in diabetic cardiomyopathy, which may be regarded as a potential clinical therapeutic target for cardiac perivascular fibrosis. |
| Date: | 2020-01 |
| Relation: | Journal of Cellular and Molecular Medicine. 2020 Jan;24(1):910-920. |
| Link to: | http://dx.doi.org/10.1111/jcmm.14800 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1582-1838&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000493885300001 |
| Cited Times(Scopus): | https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85074778816 |
| Appears in Collections: | [裘正健] 期刊論文
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| ISI000493885300001.pdf | | 1850Kb | Adobe PDF | 377 | View/Open |
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