國家衛生研究院 NHRI:Item 3990099045/12279

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Title:	IGF1 gene is associated with triglyceride levels in subjects with family history of hypertension from the SAPPHIRe and TWB projects
Authors:	Wang, W;Chiu, Y;Chung, R;Hwu, C;Lee, I;Lee, C;Chang, Y;Hung, K;Quertermous, T;Chen, YI;Hsiung, CA
Contributors:	Institute of Population Health Sciences
Abstract:	Introduction: Chromosome 12q23-q24 has been linked to triglyceride levels by linkage studies, and it contains the Insulin-like growth factor 1 (IGF1) gene. However, association between IGF1 and triglyceride levels was not well investigated and remained unclear. Materials and Methods: We investigated the association between IGF1 and triglyceride levels by using two independent samples collected in Taiwan: the ﬁ rst sample consists of 954 siblings in 397 families from the Stanford Asian Paci ﬁ c Program in Hypertension and Insulin Resistance (SAPPHIRe); the second sample consists of 13,193 unrelated subjects from the Taiwan biobank (TWB) project. Five tag single-nucleotide polymorphisms (tagSNPs) within IGF1 were analyzed. Results: First, based on the SAPPHIRe sample, we found that one IGF1 tag-SNP was associated with triglyceride levels ( β = -0.049, p = 0.0043). Then, subset analyses in the TWB sample showed that this association appeared in subjects with a family history (FH) of hypertension ( β = -0.045, p = 0.0000034), but not in subjects without an FH (p = 0.61). A re-examination of the SAPPHIRe sample con ﬁ rmed that this association appeared in subjects with an FH of hypertension ( β = -0.068, p = 0.0025), but not in subjects without an FH (p = 0.32). Conclusions: The successful replication in two independent samples indicated that IGF1 is associated with triglyceride levels in subjects with an FH of hypertension in Taiwan. This study was supported by the National Health Research Institutes (PH-104-PP03, PH-105-PP03, PH-106-PP03), the Taipei Medical University (TMU101-AE1-B67), and the Ministry of Science and Technology (MOST 106-2314-B-038-052-MY3) in Taiwan.
Date:	2019-07
Relation:	European Journal of Human Genetics. 2019 Jul;27:163.
Link to:	https://doi.org/10.1038/s41431-019-0404-7
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1018-4813&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000489313101119
Appears in Collections:	[Chao A. Hsiung] Conference Papers/Meeting Abstract [Ren-Hua Chung] Conference Papers/Meeting Abstract

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