國家衛生研究院 NHRI:Item 3990099045/1222
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    题名: Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery
    作者: Lin, YH;Mi, FL;Chen, CT;Chang, WC;Peng, SF;Liang, HF;Sung, HW
    贡献者: Division of Biotechnology and Pharmaceutical Research
    摘要: Nanoparticles (NPs) composed of chitosan (CS) and poly(gamma-glutamic acid) (gamma-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and gamma-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crystal structure of CS was disrupted after it was combined with gamma-PGA. The diameters of the prepared NPs were in the range of 110-150 nm with a negative or positive surface charge, depending on the relative concentrations of CS to gamma-PGA used. The NPs with a positive surface charge (or shelled with CS) could transiently open the tight junctions between Caco-2 cells and thus increased the paracellular permeability. After loading of insulin, the NPs remained spherical and the insulin release profiles were significantly affected by their stability in distinct pH environments. The in vivo results clearly indicated that the insulin-loaded NPs could effectively reduce the blood glucose level in a diabetic rat model.
    关键词: Biochemistry & Molecular Biology;Chemistry, Organic;Polymer Science
    日期: 2007-01
    關聯: Biomacromolecules. 2007 Jan;8(1):146-152.
    Link to: http://dx.doi.org/10.1021/bm0607776
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1525-7797&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000243337600020
    Cited Times(Scopus): http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=33846410236
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