國家衛生研究院 NHRI:Item 3990099045/12199
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 914422      線上人數 : 1387
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12199


    題名: Prognostic and clinicopathologic associations of Casein Kinase (CK) 1 alpha in acral lentiginous melanoma
    其他題名: Prognostic and clinicopathologic associations of Casein Kinase (CK) 1 α in acral lentiginous melanoma
    作者: Chang, C;Huang, S;Ito, T;Lo, Y;Shen, C;Tsai, K;Wu, T;Hsu, Y;Chang, K;Lin, T
    貢獻者: National Institute of Cancer Research
    摘要: Acral lentiginous melanoma (ALM), presenting on the palms of the hands, the soles of the feet, and the subungual area, is the most common type melanoma in Asian. Casein kinase 1α (CK1α, encoded by the CSNK1A1 gene) is involved in multiple cellular processes including gene transcription, cell division, nuclear localization, DNA repair, and carcinogenesis. CK1α has been reported as tumor promoter or tumor suppressor in different tumor types and tumor sites. In this study, we aim to investigate the role of CK1α in ALM. A total of 158 cases of ALM registered in three medical centers, two in Taiwan and one in Japan, were enrolled. We analyzed the prognostic impact of CK1α on the survival of ALM patients using the clinicopathological data and immunohistochemistry in 158 formalin-fixed paraffin-embedded samples, and examined the CSNK1A1 gene copy number variation (CNV) using droplet digital PCR in 69 samples. Patients with CK1α-high expression had significantly shorter melanoma-specific survival compared to those with CK1α-low expression (5-year survival, 45.2 % vs. 91.6 %; P < 0.001). 92.8% (64/69) of ALM had increased CNV of CSNK1A1. Higher CSNK1A1 CNV was associated with more advanced Breslow thickness. In conclusion, overexpression of CK1α is an adverse prognostic factor in ALM. CK1α may function as a tumor promoter in ALM, and a potential therapeutic target of ALM.
    日期: 2019-09
    關聯: Journal of Investigative Dermatology. 2019 Sep;139(9):S299.
    Link to: http://dx.doi.org/10.1016/j.jid.2019.07.541
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0022-202X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000485661500486
    顯示於類別:[沈哲宏] 會議論文/會議摘要

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    ISI000485661500486.pdf198KbAdobe PDF251檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋