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http://ir.nhri.org.tw/handle/3990099045/12132
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| Title: | Association between prenatal exposure to PM2.5 and atopic eczema in Asian school-age children |
| Authors: | Huang, H;Tsai, S;Wu, C;Tsai, H;Yao, T |
| Contributors: | Institute of Population Health Sciences |
| Abstract: | Background : Atopic eczema is a common inflammatory skin disease occurred in infants and children. Associations between ambient particulate matter < 2.5 μm (PM 2.5 ) and allergic diseases have been suggested in previous epidemiologic studies. However, limited cohort studies have examined the role of prenatal exposure to PM 2.5 plays in the development of childhood eczema. We aimed to evaluate whether prenatal exposure to PM 2.5 was associated with eczema in a cohort of Asian school- age children. Method : The study consists of 1169 full- term (≥37 weeks of gestation) school- aged children, part of the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort. Data related to clinical symptoms and physician- diagnosed eczema, and other pertinent demographic/ epidemiologic factors were collected using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Children with atopy were defined based on Phadiatop Infant test (≥ 0.35 PAU/L). Prenatal exposure to PM 2.5 levels were estimated by linking their residential addresses during prenatal stage to air quality monitoring stations operated by Taiwan Air Quality Monitoring Network (TAQMN). Multiple logistic regressions with covariates adjustment were carried out to examine the association of prenatal exposure to PM 2.5 with physiciandiagnosed eczema. Results : There were 426 (36.4%) children with physiciandiagnosed eczema. The risk of physician- diagnosed eczema was increased with higher exposure to PM 2.5 during entire pregnancy (adjusted odds ratio (AOR) = 1.07, 95% confidence interval: 1.01- 1.13). Particularly, higher exposure to PM 2.5 in the second trimester (AOR = 1.04, 95% CI: 1.01- 1.08), but not first or third trimesters, significantly increased the risk of physician- diagnosed eczema. In addition, results from stratified analysis suggested that exposure to PM 2.5 during entire pregnancy was positively associated with physician- diagnosed eczema among children with atopy (AOR = 1.12, 95% CI:1.04- 1.21), but not among those without atopy. In the second trimester, risk of physician- diagnosed eczema associated with PM2.5 among children with atopy (AOR = 1.05, 95% CI:1.01- 1.09) was higher than those without atopy (AOR = 1.03, 95% CI:0.97- 1.09). Conclusion : This study shows that prenatal exposure to PM 2.5 was positively associated with atopic eczema in Asian school- age children. |
| Date: | 2019-08 |
| Relation: | Allergy. 2019 Aug;74(S106):604-605. |
| Link to: | https://doi.org/10.1111/all.13961 |
| JIF/Ranking 2023: | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR |
| Cited Times(WOS): | https://www.webofscience.com/wos/woscc/full-record/WOS:000480254004011 |
| Appears in Collections: | [蔡慧如] 會議論文/會議摘要
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| ISI000480254004011.pdf | | 1576Kb | Adobe PDF | 648 | View/Open |
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