國家衛生研究院 NHRI:Item 3990099045/12131

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Title:	Prenatal exposure to PM10 levels and development of childhood eczema
Authors:	Tsai, S;Huang, H;Wu, C;Tsai, H;Yao, T
Contributors:	Institute of Population Health Sciences
Abstract:	Background : Previous studies have suggested that exposure to air pollution has increased the risk of developing childhood allergic diseases. However, the effect of prenatal exposure to particulate air pollutants, such as particulate matter with a diameter less than 10 μm (PM 10 ) on the risk of developing subsequent childhood eczema is unclear. Method : In the present study, we included 1513 children born between 2010 and 2011 and participated in the L ongitudinal I nvestigation of G lobal H ealth in T aiwanese S choolchildren (LIGHTS) Cohort. We collected the demographic, epidemiologic and phenotype data using a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Prenatal exposure to PM 10 during entire pregnancy and each trimester, respectively, was estimated based on the information provided by the Taiwan Air Quality Monitoring Network (TAQMN). We applied the ordinary kriging model coupled with land use regression model to assess the spatial- temporal variability of prenatal exposure to PM 10 . We used multiple logistic regression analysis to estimate the association between exposure to PM 10 and physician- diagnosed eczema with adjustments for potential confounders. We also performed stratified analysis by gender and atopy. Results : Analyses included 1169 full- term children (mean age, 6.4 years). Overall, 36.4% of the children had physician- diagnosed eczema. An increased risk of physician- diagnosed eczema were significantly associated with exposure to PM 10 during entire pregnancy (adjusted odds ratio (AOR) = 1.037, 95% confidence interval (CI) = (1.006- 1.069)), while the association was significant only in the second trimester (AOR = 1.020, 95%CI = (1.004- 1.036)) but not in the first or third trimesters. Stratified analyses showed that the association of second trimester exposure to PM 10 with physician- diagnosed eczema existed only in boys (AOR = 1.029, 95%CI = (1.006- 1.051)) and children with atopy (AOR = 1.021, 95%CI = (1.001- 1.041), respectively. Conclusion : Our results suggest a positive association between prenatal exposure to PM 10 , especially in the second trimester, and the development of childhood eczema.
Date:	2019-08
Relation:	Allergy. 2019 Aug;74(S106):605.
Link to:	https://doi.org/10.1111/all.13961
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000480254004012
Appears in Collections:	[Hui-Ju Tsai] Conference Papers/Meeting Abstract

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