國家衛生研究院 NHRI:Item 3990099045/12130
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 12145/12927 (94%)
造访人次 : 856769      在线人数 : 889
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于NHRI ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12130


    题名: Childhood fractional exhaled nitric oxide as a predictor of asthma symptoms in adolescence
    作者: Tsai, H;Yao, T
    贡献者: Institute of Population Health Sciences
    摘要: Background : Asthma is a common disease in pediatric populations. It affects approximately 350 million people worldwide. Fraction of exhaled nitric oxide (FeNO) is recognized as a clinical marker of airway inflammation. However, it remains unclear whether childhood FeNO levels can be served as a predictor of subsequent asthma symptoms in adolescence. This study aims to investigate the relationship between childhood FeNO levels and subsequent asthma symptoms in adolescence. Method : The study children were enrolled from the Prediction of Allergies in Taiwanese CHildren (PATCH) study, a prospective population- based cohort study launched in 2007. We measured FeNO level of each participant using a single- breath online method at enrollment, and employed a modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire to collect demographic data, general health information, and clinical data (e.g., clinical symptoms and diagnosis of allergic diseases) at enrollment and the 6- year follow- up, respectively. Multiple logistic regression models with covariates adjustment were carried out to evaluate the association of between childhood FeNO levels and longitudinal change of asthma symptoms in adolescence. Results : A total of 1210 study children were included. Among those, there were 54 (4.5%) children without physician- diagnosed asthma at enrollment, but with physician- diagnosed asthma at follow- up, defined as incidence of physician- diagnosed asthma; 113 (9.3%) children with physician- diagnosed asthma at both enrollment and follow- up, defined as persistence of physician- diagnosed asthma; and 165 (13.6%) children with physician- diagnosed asthma at enrollment, but without physician- diagnosed asthma at follow- up, defined as remission of physician- diagnosed asthma. There were positive associations between FeNO levels at enrollment and longitudinal change of asthma symptoms at follow- up (adjusted odds ratio (AOR) = 2.33, 95% confidence interval (CI):1.82- 2.99 for wheeze ever; AOR = 2.39, 95%CI:1.60- 3.56 for current wheeze; and AOR = 2.16, 95%CI:1.65- 2.84 for physician- diagnosed asthma). Positive associations between FeNO levels at enrollment and persistent asthma symptoms at follow- up, including wheeze ever (AOR = 1.82; 95%CI:1.23- 2.70), current wheeze (AOR = 2.30; 95%CI:1.06- 4.98) and physician- diagnosed asthma (AOR = 1.73; 95%CI:1.01- 2.96) were also observed.
    日期: 2019-08
    關聯: Allergy. 2019 Aug;74(S106):383-384.
    Link to: https://doi.org/10.1111/all.13961
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0105-4538&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000480254003016
    显示于类别:[蔡慧如] 會議論文/會議摘要

    文件中的档案:

    档案 描述 大小格式浏览次数
    ISI000480254003016.pdf1618KbAdobe PDF244检视/开启


    在NHRI中所有的数据项都受到原著作权保护.

    TAIR相关文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈