國家衛生研究院 NHRI:Item 3990099045/12123
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 855370      線上人數 : 1059
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12123


    題名: Delivery of antigen to CD8(+) dendritic cells by fusing antigen with formyl peptide receptor-like 1 inhibitor protein induces antitumor immunity
    作者: Chiang, CY;Wu, CC;Chen, YJ;Liu, SJ;Leng, CH;Chen, HW
    貢獻者: National Institute of Infectious Diseases and Vaccinology
    摘要: A major challenge for vaccine development is targeting antigens to dendritic cells (DCs) in vivo, enabling cross-presentation, and inducing the memory responses. Fcgamma receptors (FcgammaRs) are expressed on many cell types including DCs. Therefore, targeting of antigen to DCs via FcgammaRs is an attractive strategy for vaccine development. This study employ formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcgammaR binding protein secreted by Staphylococcus aureus, to deliver antigen to DCs. Our results show that FLIPr is a competent vehicle in delivering antigen to CD8(+) DCs for induction of potent immunities without extra adjuvant formulation. Fusion antigen with FLIPr enables effective antigen presentation on both MHC class II and class I to induce memory T cell responses. Altogether, using FLIPr as an antigen delivery vector has great potential to apply antigens for cancer immunotherapy as well as other infectious disease vaccines.
    日期: 2019-08-02
    關聯: Frontiers in Immunology. 2019 Aug 2;10:Article number 1839.
    Link to: http://dx.doi.org/10.3389/fimmu.2019.01839
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1664-3224&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000478586100001
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85071575190
    顯示於類別:[陳信偉] 期刊論文
    [冷治湘] 期刊論文
    [劉士任] 期刊論文

    文件中的檔案:

    檔案 大小格式瀏覽次數
    PUB31428106.pdf3343KbAdobe PDF385檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋