國家衛生研究院 NHRI:Item 3990099045/12118
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    題名: Changes in mitochondrial genome associated with predisposition to atherosclerosis and related disease
    作者: Volobueva, A;Grechko, A;Yet, SF;Sobenin, I;Orekhov, A
    貢獻者: Institute of Cellular and Systems Medicine
    摘要: Atherosclerosis-related cardiovascular diseases remain the leading cause of morbidity and mortality, and the search for novel diagnostic and therapeutic methods is ongoing. Mitochondrial DNA (mtDNA) mutations associated with atherosclerosis represent one of the less explored aspects of the disease pathogenesis that may bring some interesting opportunities for establishing novel molecular markers and, possibly, new points of therapeutic intervention. Recent studies have identified a number of mtDNA mutations, for which the heteroplasmy level was positively or negatively associated with atherosclerosis, including the disease at its early, subclinical stages. In this review, we summarize the results of these studies, providing a list of human mtDNA mutations potentially involved in atherosclerosis. The molecular mechanisms underlying such involvement remain to be elucidated, although it is likely that some of them may be responsible for the increased oxidative stress, which plays an important role in atherosclerosis.
    日期: 2019-08-18
    關聯: Biomolecules. 2019 Aug 18;9(8):Article number 377.
    Link to: http://dx.doi.org/10.3390/biom9080377
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2218-273X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000484457600082
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85071600835
    顯示於類別:[林秀芳] 期刊論文

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