國家衛生研究院 NHRI:Item 3990099045/12097

NHRI > Institute of Biomedical Engineering and Nanomedicine > Lun-De Liao > Conference Papers/Meeting Abstract > Item 3990099045/12097

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12097

Title:	Real-time ultrasound/photoacoustic imaging system and its in vitro/in vivo applications
Authors:	Liao, LD
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Objectives: Photoacoustic (PA) imaging has become an attractive method for imaging biological tissues due to its capacity to capture both functional and structure information with satisfied spatial resolution. Current commercialized PA imaging systems on the market are limited by their bulky size or inflexible user interface. Here, we present a new HAndheld Real-time ultrasound/Photoacoustic imaging system (HARP) consisting of a detachable fiber bundle-based illumination system integrated with an array-based ultrasound transducer and data acquisition platform. In this system, different PA probes can be adapted for different imaging applications by switching the transducers and the corresponding jackets to fix the fiber pads and transducer in a single setting. The intuitive user interface of the system is a completely programmable MATLAB-based platform. In vitro phantom experiments were conducted to reveal the imaging performance of the developed PA system. We further demonstrated 1) in vivo brain vasculature imaging, 2) in vivo real-time stimulus-evoked cortical hemodynamic changes during forepaw electrical stimulation, and 3) in vivo real-time cerebral pharmacokinetics in rats using the developed PA system. Collectively, this design concept of a customizable ultrasound/photoacoustic imaging system is intended to help overcome the diverse challenges faced by medical researchers performing both preclinical and clinical PA studies.
Date:	2019-07
Relation:	Journal of Cerebral Blood Flow and Metabolism. 2019 Jul;39:623-623.
Link to:	https://journals.sagepub.com/doi/full/10.1177/0271678X19850989
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0271-678X&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000473954100807
Appears in Collections:	[Lun-De Liao] Conference Papers/Meeting Abstract

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