國家衛生研究院 NHRI:Item 3990099045/12092
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 912369      線上人數 : 1166
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12092


    題名: The preparation of oxidized methylcellulose crosslinked by adipic acid dihydrazide loaded with vitamin C for traumatic brain injury
    作者: Kuan, CY;Lin, YY;Chen, CY;Yang, CC;Chi, CY;Li, CH;Dong, GC;Lin, FH
    貢獻者: Institute of Biomedical Engineering and Nanomedicine
    摘要: Traumatic brain injury (TBI) is defined as the destruction or degeneration of brain cells due to external force. Free radical generation from the damage site is the major factor that causes post-therapeutic failure in TBI patient. In this study, an oxi-methylcellulose-adipic acid dihydrazide (oxi-MC-ADH) hydrogel was prepared as a vitamin C carrier for TBI in emergency that continuously releases vitamin C at the injured site in the brain. The results show that the oxi-MC-ADH hydrogel exhibits adequate gelation time and good biocompatibility in vitro. Vitamin C incorporated in the oxi-MC-ADH hydrogel (oxi-MC-ADH-VC) initially burst released in the first 6 h to serve as a primary treatment and then extendedly released for the secondary treatment. The analysis of gene expression and reactive oxygen species production was done to demonstrate the neuroprotective effects of the hydrogel. In vivo neurological function assays and behavioral tests show a significant improvement in the outcome in rats with TBI 3 weeks after the oxi-MC-ADH-VC hydrogel injection. This study demonstrates that the oxi-MC-ADH-VC hydrogel has a great potential in the management of TBI.
    日期: 2019-07
    關聯: Journal of Materials Chemistry B. 2019 Jul;7(29):4499-4508.
    Link to: http://dx.doi.org/10.1039/c9tb00816k
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2050-750X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000477575700011
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069752046
    顯示於類別:[林峯輝] 期刊論文
    [董國忠] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    SCP85069752046.pdf4782KbAdobe PDF373檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋