國家衛生研究院 NHRI:Item 3990099045/12087

NHRI > Institute of Biomedical Engineering and Nanomedicine > Chia-Wen Wu > Periodical Articles > Item 3990099045/12087

Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/12087

Title:	Acute oral toxicity and repeated dose 28-day oral toxicity studies of MIL-101 nanoparticles
Authors:	Liu, CH;Chiu, HC;Sung, HL;Yeh, JY;Wu, KC;Liu, SH
Contributors:	Institute of Biomedical Engineering and Nanomedicine
Abstract:	Metal-organic frameworks (MOFs) nanoparticles are a class of porous crystalline materials constructed from the bonding metal ions or clusters linked with organic ligands to form frameworks. MIL-101(Cr), one of the most representative MOFs, is a three-dimensional chromium terephthalate-base porous material consisted of chromium (III)-trimers cross-linked by 1,4-benzene dicarboxylate. The present study focused on determining the safety of MIL-101(Cr) nanoparticle. The acute oral toxicity and 28-day oral toxicity in mice were investigated. An acute oral toxicity test of MIL-101(Cr) nanoparticle for female mice showed that no mortality or any significant change observed at 2000mg/kg body weight. A dose-dependent 28-day oral toxicity evaluation of MIL-101(Cr) nanoparticle for male and female mice revealed no significant effects on mortality, feed consumption, body weight, organ weight, and behavior. Assessments of hematology, clinical biochemistry, and histopathology revealed no adverse effects in mice treated with MIL-101(Cr) nanoparticle (10-1000mg/kg). These results suggest that MIL-101(Cr) nanoparticle has no significant acute and subacute toxicity. The no observed adverse effect level of MIL-101(Cr) nanoparticle was defined as at least 1000mg/kg/day orally for 28 days for male and female mice.
Date:	2019-10
Relation:	Regulatory Toxicology and Pharmacology. 2019 Oct;107:Article number 104426.
Link to:	http://dx.doi.org/10.1016/j.yrtph.2019.104426
JIF/Ranking 2023:	http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=0273-2300&DestApp=IC2JCR
Cited Times(WOS):	https://www.webofscience.com/wos/woscc/full-record/WOS:000513225500031
Cited Times(Scopus):	https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069594280
Appears in Collections:	[Chia-Wen Wu] Periodical Articles

Files in This Item:

File	Size	Format
PUB31325534.pdf	1495Kb	Adobe PDF	264	View/Open

Loading...