國家衛生研究院 NHRI:Item 3990099045/12051
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 12145/12927 (94%)
造訪人次 : 916715      線上人數 : 1504
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧：
  • 您可在西文檢索詞彙前後加上"雙引號"，以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋，建議至進階搜尋限定作者欄位，可獲得較完整資料
    •  進階搜尋
    主頁 ‧ 登入 ‧ 上傳 ‧ 說明 ‧ 關於NHRI ‧ 管理 到手機版


    請使用永久網址來引用或連結此文件: http://ir.nhri.org.tw/handle/3990099045/12051


    題名: Temporal distribution and biological determinants of thrombotic events after interventions for dialysis vascular access
    作者: Hsieh, MY;Lee, CK;Lo, CM;Chen, CH;Chuang, SY;Wu, CC
    貢獻者: Institute of Population Health Sciences
    摘要: Endovascular therapy is the principal therapy for haemodialysis vascular access dysfunction. Nonetheless, the incidence and determinants of post-intervention thrombotic events are unclear. This prospective cohort study evaluated the incidence and timing of thrombotic events after endovascular therapy and analysed the clinical, angiographic, and biological determinants of thrombosis. Of the 236 patients enrolled, 91 experienced post-intervention thrombotic events within 1 year. The 1-year thrombosis-free patency was 28% for thrombosed accesses, 53% for non-thrombosed grafts, and 78% for non-thrombosed fistulas. Forty-one of the 91 thrombotic events (45%) occurred within 3 months post-intervention. In the univariate analysis, early thrombosis was associated with longer haemodialysis duration (hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.01-1.02), graft access (HR, 7.69; 95% CI, 3.33-20.0), multiple stenoses (HR, 2.69; 95% CI, 1.36-5.37), and high indoxyl sulphate (IS) levels (HR, 1.55; 95% CI, 1.32-1.82). Late thrombosis was associated with diabetes (HR, 1.89; 95% CI, 1.01-3.57), cardiovascular disease (HR, 2.38; 95% CI, 1.27-4.54), and endothelial progenitor cell counts (HR, 0.97; 95% CI, 0.93-0.99). After multivariate adjustment, high IS was the major predisposing factor for early post-intervention thrombosis (HR, 1.41; 95% CI, 1.18-1.69). Our findings suggest that measures to decrease IS could target the most critical period of thrombosis.
    日期: 2019-07-24
    關聯: Scientific Reports. 2019 Jul 24;9:Article number 10720.
    Link to: http://dx.doi.org/10.1038/s41598-019-47293-3
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2045-2322&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000476874600018
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85069643260
    顯示於類別:[莊紹源] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    PUB31341259.pdf1347KbAdobe PDF247檢視/開啟


    在NHRI中所有的資料項目都受到原著作權保護.

    TAIR相關文章

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋