國家衛生研究院 NHRI:Item 3990099045/11995
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    Please use this identifier to cite or link to this item: http://ir.nhri.org.tw/handle/3990099045/11995


    Title: Poly-Gamma-Glutamic acid functions as an eective lubricant with antimicrobial activity in multipurpose contact lens care solutions
    Authors: Su, CY;Tseng, CL;Wu, SH;Shih, BW;Chen, YZ;Fang, HW
    Contributors: Institute of Biomedical Engineering and Nanomedicine
    Abstract: In order to perform the multiple functions of disinfection, cleansing, and storage, preservatives are often added to contact lens care solutions. The disadvantage of adding preservatives is that this often causes various eye conditions. However, lens care solutions would not be able to disinfect in the absence of such preservatives. In addition, comfort is an important issue for contact lens wearers due to the long periods of time they are worn. It has been shown that lower friction coefficients are correlated with increased comfort. We have previously developed a multipurpose contact lens care solution in which poly-gamma-glutamic acid (gamma-PGA) was the main ingredient. In this study, we investigated the antimicrobial activity and lubricating property of our care solution. We showed that there was a synergetic effect of gamma-PGA and chlorine dioxide on antimicrobial activity. We also demonstrated that gamma-PGA functioned as a lubricating agent. Our results provided evidence of gamma-PGA acting as a multi-functional polymer that could be applied in contact lens care solutions.
    Date: 2019-06-16
    Relation: Polymers. 2019 Jun 16;11(6):Article number 1050.
    Link to: http://dx.doi.org/10.3390/polym11061050
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=2073-4360&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000473819100122
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067349726
    Appears in Collections:[Others] Periodical Articles

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