國家衛生研究院 NHRI:Item 3990099045/11993
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    题名: The multifaceted role of mesenchymal stem cells in cancer
    作者: Timaner, M;Tsai, K;Shaked, Y
    贡献者: National Institute of Cancer Research
    摘要: Mesenchymal stem cells (MSCs) are multipotent stem cells derived from the mesoderm that give rise to several mesenchymal lineages, including osteoblasts, adipocytes, chondrocytes and myocytes. Their potent ability to home to tumors coupled with their differentiation potential and immunosuppressive function positions MSCs as key regulators of tumor fate. Here we review the existing knowledge on the involvement of MSCs in multiple tumor-promoting processes, including angiogenesis, epithelial-mesenchymal transition, metastasis, immunosuppression and therapy resistance. We also discuss the clinical potential of MSC-based therapy for cancer.
    日期: 2020-02
    關聯: Seminars in Cancer Biology. 2020 Feb;60:225-237.
    Link to: http://dx.doi.org/10.1016/j.semcancer.2019.06.003
    JIF/Ranking 2023: http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=NHRI&SrcApp=NHRI_IR&KeyISSN=1044-579X&DestApp=IC2JCR
    Cited Times(WOS): https://www.webofscience.com/wos/woscc/full-record/WOS:000520016500020
    Cited Times(Scopus): https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=85067352621
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